NORMALIZATION OF THE TUMOR MICROENVIRONMENT BY HARNESSING VASCULAR AND IMMUNE MODULATION TO ACHIEVE ENHANCED CANCER THERAPY

Normalization of the tumor microenvironment by harnessing vascular and immune modulation to achieve enhanced cancer therapy

Abstract Solid tumors are complex entities that actively shape their microenvironment to create a supportive environment for their own growth.Angiogenesis and immune suppression are two key characteristics of this tumor microenvironment.Despite attempts to deplete tumor blood vessels using antiangiogenic drugs, extensive vessel pruning has shown CL

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Self-fertility in Chromocrea spinulosa is a consequence of direct repeat-mediated loss of MAT1-2, subsequent imbalance of nuclei differing in mating type, and recognition between unlike nuclei in a common cytoplasm.

The filamentous fungus Chromocrea spinulosa (Trichoderma spinulosum) exhibits both self-fertile (homothallic) and self-sterile (heterothallic) sexual reproductive behavior.Self-fertile strains produce progeny cohorts that are 50% homothallic, 50% heterothallic.Heterothallic progeny can mate only with homothallic strains, and progeny also segregate

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